full list (Updated feb 22, 2024)
click here for a list of preprints that have not yet finished the peer-review process
“Multimodal probing of T-cell recognition with hexapod heterostructures.” Xiaodan Huang, Lingyuan Meng, Guoshuai Cao, Aleksander Prominski, Yifei Hu, Chuanwang Yang, Min Chen, Jiuyun Shi, Charles Gallagher, Thao Cao, Jiping Yue, Jun Huang, Bozhi Tian. Nature Methods. 2024. Download.
“A single-cell atlas reveals shared and distinct immune responses and metabolic profiles in SARS-CoV-2 and HIV-1 infections.” Tony Pan, Guoshuai Cao, Erting Tang, Yu Zhao, Pablo Penaloza-MacMaster, Yun Fang, Jun Huang. Frontiers in Genetics, 2023. Download.
“Rapid, Sensitive, Label-Free Electrical Detection of SARS-CoV-2 in Nasal Swab Samples,” Hyun-June Jang, Wen Zhuang, Xiaoyu Sui, Byunghoon Ryu, Xiaodan Huang, Min Chen, Xiaolei Cai, Haihui Pu, Kathleen Beavis, Jun Huang, Junhong Chen. ACS Appl. Mater. Interfaces, 2023. Download.
“Remote Floating-Gate Field-Effect Transistor with 2-Dimensional Reduced Graphene Oxide Sensing Layer for Reliable Detection of SARS-CoV-2 Spike Proteins.” Hyun-June Jang, Xiaoyu Sui, Wen Zhuang, Xiaodan Huang, Min Chen, Xiaolei Cai, Yale Wang, Byunghoon Ryu, Haihui Pu, Nicholas Ankenbruck, Kathleen Beavis, Jun Huang, Junhong Chen. ACS Appl. Mater. Interfaces, 2023. Download.
“A computational algorithm to assess the physiochemical determinants of T cell receptor dissociation kinetics,” Zachary A Rollins, Jun Huang, Ilias Tagkopoulos, Roland Faller, Steven C George. Comput Struct Biotechnol J, 2023. Download.
“CD4+ T-cell epitope-based heterologous prime-boost vaccination potentiates anti-tumor immunity and PD-1/PD-L1 immunotherapy,” Minglu Xiao, Luoyingzi Xie, Guoshuai Cao, Shun Lei, Pengcheng Wang, Zhengping Wei, Yuan Luo, Jingyi Fang, Xingxing Yang, Qizhao Huang, Lifan Xu, Junyi Guo, Shuqiong Wen, Zhiming Wang, Qing Wu, Jianfang Tang, Lisha Wang, Xiangyu Chen, Cheng Chen, Yanyan Zhang, Wei Yao, Jianqiang Ye, Ran He, Jun Huang, Lilin Ye. Journal for Immunotherapy of Cancer, 2022. Download.
“Remote Floating-Gate Field-Effect Transistor with 2-Dimensional Reduced Graphene Oxide Sensing Layer for Reliable Detection of SARS-CoV-2 Spike Proteins,” Hyun-June Jang, Xiaoyu Sui, Wen Zhuang, Xiaodan Huang, Min Chen, Xiaolei Cai, Yale Wang, Byunghoon Ryu, Haihui Pu, Nicholas Ankenbruck, Kathleen Beavis, Jun Huang, Junhong Chen. ACS Applied Materials and Interfaces, 2022. Download.
“A computational algorithm to assess the physiochemical determinants of T cell receptor dissociation kinetics,” Zachary Rollins, Jun Huang, Ilias Tagkopoulos, Roland Faller, Steven C George. Computational and Structural Biotechnology Journal, 2022. Download.
“A Multifunctional Neutralizing Antibody-Conjugated Nanoparticle Inhibits and Inactivates SARS-CoV-2,” Xiaolei Cai, Min Chen, Aleksander Prominski, Yiliang Lin, Nicholas Ankenbruck, Jillian Rosenberg, Mindy Nguyen, Jiuyun Shi, Anastasia Tomatsidou, Glenn Randall, Dominique Missiakas, John Fung, Eugene B Chang, Pablo Penaloza-MacMaster, Bozhi Tian, Jun Huang. Advanced Science, 2021. Download.
“Antigen multimers: Specific, sensitive, precise, and multifunctional high-avidity CAR-staining reagents,” Yifei Hu, Guoshuai Cao, Xiufen Chen, Xiaodan Huang, Nicholas Asby, Nicholas Ankenbruck, Ali Rahman, Ashima Thusu, Yanran He, Peter A. Riedell, Michael R. Bishop, Hans Schreiber, Justin P. Kline, Jun Huang. Matter, 2021. Download.
“Single-cell lactate production rate as a measure of glycolysis in endothelial cells,” Devin Harrison, David Wu, Jun Huang, Yun Fang. STAR Protocols, 2021. Download.
“Single-cell metabolic imaging reveals a RhoA-triggered glycolytic burst in motile endothelial cells,” David Wu, Devin Harrison, Teodora Szasz, Chih-Fan Yeh, Tzu-Pin Shentu, Angelo Meliton, Ru-Ting Huang, Zhengjie Zhou, Gokhan Mutlu, Jun Huang, Yun Fang. Nature Metabolism, 2021. Download.
“Improved integration of single-cell transcriptome and surface protein expression by LinQ-View,” Lei Li, Haley L. Dugan, Christopher T. Stamper, Linda Yu-Ling Lan, Nicholas W. Asby, Matthew Knight, Olivia Stovicek, Nai-Ying Zheng, Maria Lucia Madariaga, Kumaran Shanmugarajah, Maud O. Jansen, Siriruk Changrob, Henry A. Utset, Carole Henry, Christopher Nelson, Robert P. Jedrzejczak, Daved H. Fremont, Andrzej Joachimiak, Florian Krammer, Jun Huang, Aly A.Khan, Patrick C. Wilson. Cell Reports Methods, 2021. Download.
“Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets,” Haley Dugan, Christopher Stamper, Lei Li, Siriruk Changrob, Nicholas Asby, Peter Halfmann, Nai-Ying Zheng, Min Huang, Dustin Shaw, Mari Cobb, Steven Erickson, Jenna Guthmiller, Olivia Stovicek, Jiaolong Wang, Emma Winkler, Maria Lucia Madariaga, Kumaran Shanmugarajah, Maud Jansen, Fatima Amanat, Isabelle Stewart, Henry Utset, Jun Huang, Christopher Nelson, Ya-Nan Dai, Paige Hall, Robert Jedrzejczak, Andrzej Joachimiak; Florian Krammer, Michael Diamond, Daved Fremont, Yoshihiro Kawaoka, Patrick C. Wilson. Immunity, 2021. Download.
“Nanotraps for the containment and clearance of SARS-CoV-2", Min Chen, Jillian Rosenberg, Xiaolei Cai, Andy Chao, Hsuan Lee, Jiuyun Shi, Mindy Nguyen, Thirushan Wignakumar, Vikranth Mirle, Arianna Joy Edobor, John Fung, Jessica Scott Donington, Kumaran Shanmugarajah, Yiliang Lin, Eugene Chang, Glenn Randall, Pablo Penaloza-MacMaster, Bozhi Tian, Maria Lucia Madariaga, Jun Huang. Matter. 2021. Download
“Primary resistance to CD19-directed chimeric antigen receptor T-cell therapy in T-cell/histiocyte-rich large B-cell lymphoma,” Jonathan A Trujillo, James Godfrey, Yifei Hu, Jun Huang, Sonali M Smith, Matthew J Frigault, Zachariah DeFilipp, Daniel Appelbaum, Yonglin Pu, Nicholas Feinberg, Thomas Althaus, Michael R Bishop, Peter A Riedell, Justin Kline. Blood. 2021. Download.
“The Chimeric Antigen Receptor Detection Toolkit,” Yifei Hu, Jun Huang. Frontiers in Immunology, 2020. Download.
“Lattice light-sheet microscopy Multi-Dimensional Analyses (LaMDA) of T-cell receptor dynamics predict T-cell signaling states,” Rosenberg, J., Cao, D., Borja-Prieto, F., Huang, J. Cell Systems, 2020. Download
“Visualizing Surface T-Cell Receptor Dynamics Four-Dimensionally Using Lattice Light-Sheet Microscopy,” J Rosenberg, J Huang. Journal of Visualized Experiments, 2020. Link
“Cyclodextrin‐Derived Intrinsically Bioactive Nanoparticles for Treatment of Acute and Chronic Inflammatory Diseases,” Jiawei Guo, Dandan Li, Hui Tao, Gang Li, Renfeng Liu, Yin Dou, Taotao Jin, Lanlan Li, Jun Huang, Houyuan Hu, Jianxiang Zhang. Advanced Materials, 2019. Download
“TCR–pMHC bond conformation controls TCR ligand discrimination,” Dibyendu K. Sasmal, Wei Feng, Sobhan Roy, Peter Leung, Yanran He, Chufan Cai, Guoshuai Cao, Huada Lian, Jian Qin, Enfu Hui, Hans Schreiber, Erin J. Adams and Jun Huang. Cellular and Molecular Immunology, 2019. Download
“A Proresolving Peptide Nanotherapy for Site‐Specific Treatment of Inflammatory Bowel Disease by Regulating Proinflammatory Microenvironment and Gut Microbiota,” Chenwen Li, Yang Zhao, Juan Cheng, Jiawei Guo, Qixiong Zhang, Xiangjun Zhang, Jiong Ren, Fengchao Wang, Jun Huang, Houyuan Hu, Ruibing Wang, Jianxiang Zhang. Advanced Science, 2019. Download
“T-Cell Mechanobiology: Force sensation, potentiation, and translation,” Devin L. Harrison, Yun Fang and Jun Huang. Frontiers in Physics, 2019. Download
“The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection,” Xiangyu Chen, Guoshuai Cao, Jialin Wu, Xinxin Wang, Zhiwei Pan, Jianbao Gao, Qin Tian, Lifan Xu, Zhirong Li, Yaxing Hao, Qizhao Huang, Pengcheng Wang, Minglu Xiao, Luoyingzi Xie, Shupei Tang, Zhenyu Liu, Li Hu, Jianfang Tang, Ran He, Li Wang, Xinyuan Zhou, Yuzhang Wu, Mengjie Chen, Beicheng Sun, Bo Zhu, Jun Huang & Lilin Ye. Cellular and Molecular Immunology, 2019. Download
“A self-illuminating nanoparticle for inflammation imaging and cancer therapy,” Xu, X., An, H., Zhang, D., Tao, H., Dou, Y., Li, X., Huang, J. and Zhang, J. Science Advances, 2018 Download.
“Stable, small, specific, low-valency quantum dots for single-molecule imaging,” Jungmin Lee, Xinyi Feng, Ou Chen, Moungi G Bawendi, Jun Huang. Nanoscale, 10, 2018 Download
“CD8+ T cells and NK cells: parallel and complementary soldiers of immunotherapy,” Jillian Rosenberg, Jun Huang. Current Opinion in Chemical Engineering, 19, 9-20, 2018 Download
“Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells ,” Yunlong Zhao, Devin L. Harrison, Yuran Song, Jie Ji, Jun Huang, Enfu Hui. Cell Reports, 24, p379–390.e6, 2018 Download
“The receptor repertoire and functional profile of follicular T cells in HIV-infected lymph nodes,” Ben S. Wendel, Daniel Del Alcazar, Chenfeng He, Perla M. Del Río-Estrada, Benjamas Aiamkitsumrit, Yuria Ablanedo-Terrazas, Stefany M. Hernandez, Ke-Yue Ma, Michael Betts, Laura Pulido, Jun Huang, Phyllis A. Gimotty, Gustavo Reyes-Terán, Ning Jiang, Laura F. Su. Science Immunology, 2018 Download
“Cathepsin-Mediated Cleavage of Peptides from Peptide Amphiphiles Leads to Enhanced Intracellular Peptide Accumulation,” Handan Acar, Ravand Samaeekia, Mathew R Schnorenberg, Dibyendu K Sasmal, Jun Huang, Matthew V Tirrell, James L LaBelle. Bioconjugate Chemistry, 28, 2316-2326, 2017 Download
“A myeloperoxidase-responsive and biodegradable luminescent material for real-time imaging of inflammatory diseases,” Jiawei Guo, Hui Tao, Yin Dou, Lanlan Li, Xiaoqiu Xu, Qixiong Zhang, Juan Cheng, Songling Han, Jun Huang, Xiaodong Li, Xiaohui Li, Jianxiang Zhang. Materials Today, 20, 493-500, 2017 Download
“T cell co-stimulatory receptor CD28 is a primary target for PD-1–mediated inhibition,” Enfu Hui, Jeanne Cheung, Jing Zhu, Xiaolei Su, Marcus J Taylor, Heidi A Wallweber, Dibyendu K Sasmal, Jun Huang, Jeong M Kim, Ira Mellman, Ronald D Vale. Science, 2017 Download
“Single-molecule fluorescence resonance energy transfer in molecular biology,” Dibyendu K Sasmal, Laura E Pulido, Shan Kasal, Jun Huang. Nanoscale, 8, 19928-19944, 2016 Download
“Detection, phenotyping and quantification of antigen-specific T cells using a peptide-MHC dodecamer,” J. Huang, X. Zeng, N. Sigal, P. J. Lund, L.F. Su, H. Huang, Chien, S. and M. M. Davis. Proceedings of the National Academy of Sciences, 2016 Download
———————— note: UChicago lab established July 2015 ————————
“Gamma delta T cells recognize haptens and mount a hapten-specific response,” Xun Zeng, Christina Meyer, Jun Huang, Evan W Newell, Brian A Kidd, Yu-Ling Wei, Yueh-hsiu Chien. eLife, 3, e03609, 2014 Download
“Insights from in situ analysis of TCR–pMHC recognition: response of an interaction network,” Cheng Zhu, Ning Jiang, Jun Huang, Veronika I Zarnitsyna, Brian D Evavold. Immunological Reviews, 251, 49-64, 2013 Download
“A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4+ T cells,” J. Huang, M. Brameshuber, X. Zeng, J. Xie, Q. Li, Y. Chien, S. Valitutti, and M.M. Davis. Immunity, 39, 836-857, 2013 Download
“T cell antigen recognition at the cell membrane,” Jun Huang, Christina Meyer, Cheng Zhu. Molecular immunology, 52, 155-164, 2012 Download
“γδ T cells recognize common B cell antigens to initiate IL-17 response,” X. Zeng, Y. Wei, J. Huang, E.W. Newell, B.A. Kidd, M.S. Kuhns, C.T. Weaver, M.M. Davis, and Y. Chien. Immunity, 37, 524-534, 2012 Download
“Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC,” J. Xie, J.B. Huppa, E.W. Newell, J. Huang, P.J. Ebert, Q.J. Li, and M.M. Davis. Nature Immunology, 13, 674-680, 2012 Download
“High prevalence of low affinity peptide–MHC II tetramer–negative effectors during polyclonal CD4+ T cell responses,” Joseph J Sabatino, Jun Huang, Cheng Zhu, Brian D Evavold. Journal of Experimental Medicine, 208, 81-90, 2011 Download
“Two-stage cooperative T cell receptor-peptide major histocompatibility complex-CD8 trimolecular interactions amplify antigen discrimination,” N. Jiang*, J. Huang*, L.J. Edwards, B. Liu, Y. Zhang, C.D. Beal, B.D. Evavold, and C. Zhu. Immunity, 34, 13-23, 2011 Download
“The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.,” J. Huang, V.I. Zarnitsyna, B. Liu, L.J. Edwards, N. Jiang, B.D Evavold, and C. Zhu. Nature, 464, 932-936, 2010 Download
“Measuring receptor–ligand binding kinetics on cell surfaces: from adhesion frequency to thermal fluctuation methods,” Wei Chen, Veronika I Zarnitsyna, Krishna K Sarangapani, Jun Huang, Cheng Zhu. Cellular and molecular bioengineering, 1, 276, 2008 Download
“Memory in receptor–ligand-mediated cell adhesion,” Veronika I Zarnitsyna, Jun Huang, Fang Zhang, Yuan-Hung Chien, Deborah Leckband, Cheng Zhu. Proceedings of the National Academy of Sciences, 104, 18037-18042, 2007 Download
“Kinetics of MHC-CD8 interaction at the T cell membrane,” Jun Huang, Lindsay J Edwards, Brian D Evavold, Cheng Zhu. The Journal of Immunology, 179, 7653-7662, 2007 Download
“Quantifying the effects of molecular orientation and length on two-dimensional receptor-ligand binding kinetics,” Jun Huang, Juan Chen, Scott E Chesla, Tadayuki Yago, Padmaja Mehta, Rodger P McEver, Cheng Zhu, Mian Long. Journal of Biological Chemistry, 2004 Download
“Kinetics of molecular interactions across the T cell–APC junction.,” Veronika I Zarnitsyna, Ning Jiang, Jun Huang, Baoyu Liu, Lindsay Edwards, Brian Evavold, Cheng Zhu. Download
“A Micropipet Aspiration System to Measure the Kinetics of Selectin/Ligand Interactions,” Jun Huang, Juan Chen, Mian Long, Cheng Zhu. International Journal of Nonlinear Sciences and Numerical Simulation, 3, 199-202, 2002